대한뉴팜

Daehan New Pharm Co., Ltd. (054670) has promoted the license-in of internal and external deworming products for companion animals through a strategic partnership with the Irish pharmaceutical company Chanelle Pharma Group, established in 2018. As a result, in January 2020, the company launched ‘Fipnil Spot-On,’ an animal pharmaceutical product containing the active ingredient ‘Fipronil.’ Fipronil is a phenylpyrazole compound that, when applied directly to companion animals, binds to GABA receptors in the nervous system of external parasites such as fleas and ticks. It acts as an antagonist to chloride ion channels, causing hyperpolarization that leads to parasite death. When applied to the skin of the companion animal's shoulder blade area (between both shoulders), the product spreads over the body within 24 hours through the lipid-rich layer of the skin. It concentrates and is stored in sebaceous glands and hair follicles under the skin, maintaining its effect by being released through the skin and hair for more than a month. Based on the advanced technology of Chanelle Pharma Group that maximizes the action mechanism of Fipronil, ‘Fipnil Spot-On’ has demonstrated superior product efficacy through bioequivalence tests and comparisons with original products tested not only in the EU but also in multiple countries worldwide. According to the “Survey Report on Companion Animal Ownership and Public Awareness (2017)” by the Korea Pet Food Association, among 19.56 million households in Korea, 5.63 million (28.8%) own companion animals. The estimated number of companion dogs is about 6.6 million, and companion cats about 2.07 million. Companion animal ownership has increased roughly 57% over the past five years, and this trend is expected to continue due to factors such as nuclear family structure, an increase in single-person households, aging population, and higher income levels. Additionally, the rise in vector insects due to global warming and increased contact between companion animals and wildlife vectors pose ongoing challenges. Therefore, prevention through internal and external antiparasitic products for companion animals is essential to protect both animal and owner health. The domestic market for such products has grown to over 20 billion won. The head of Daehan New Pharm's animal pharmaceuticals division stated, “By supplying the competitively positioned ‘Fipnil Spot-On’ developed through strategic cooperation with Chanelle Pharma Group’s technology, we expect to become a leading player in the steadily growing domestic internal and external deworming market for companion animals.”

The vitamin D injection product 'Vita D Injection' was recognized for its stability and won the Formulation Technology Award at the 2019 International Conference of the Korean Pharmaceutical Society. The award-winning technology involves suppressing the formation of soft substances (degradants) in the vitamin D injection, securing its stability, and changing the storage temperature approval from 1–25℃ to 1–30℃. This improvement increases convenience in distribution and storage. Currently, Daehan New Pharm is the only company producing vitamin D injections under the 1–30℃ storage condition. Vitamin D, specifically calciferol, is classified into D2 (ergocalciferol) and D3 (cholecalciferol). D2 is made from ergosterol, a sterol, while D3 is produced in the skin upon sunlight exposure to 7-dehydrocholesterol. Vitamin D is known for promoting calcium absorption and is part of osteoporosis treatments. Recently, its deficiency has been linked to obesity, diabetes, and heart disease. Despite the growing importance of vitamin D, modern lifestyles with reduced outdoor activity and frequent use of sunscreen make deficiency common. Since vitamin D3 easily oxidizes to form unstable soft substances, developing vitamin D injections has been challenging. Daehan New Pharm secured stabilization technology that inhibits the formation of soft substances like trans-cholecalciferol. The company registered two related patents and successfully changed storage conditions to improve convenience. The domestic market for vitamin D injections grew from 12.3 billion won in 2017 to 13.2 billion won in 2018. Daehan New Pharm produces and sells three dosage forms of 'Vita D': 100,000 IU, 200,000 IU, and 300,000 IU.

In the third quarter of 2019, Daehan New Pharm recorded cumulative sales of 98.9 billion won, representing a 10% increase compared to the same period the previous year. Operating profit rose approximately 9% year-on-year to 16.1 billion won, with an operating margin of 16.3%. Net profit also significantly increased to 9.8 billion won, reflecting a net profit margin of 9.9%. The company is divided into four main business sectors: pharmaceutical, animal pharmaceuticals, overseas business, and bio business. The pharmaceutical division, which accounts for the largest share of sales, is further categorized into reimbursed drugs, non-reimbursed drugs, and obesity and well-being injections. In 2019, sales growth was driven by new reimbursed products. Expected sales of approximately 2 billion won are projected from three products: "Hyaleum injection" for joint pain, "Newpogrel SR" effective for chronic arterial occlusion, and "NPiren S," a gastric mucosal protector. The launch of "Fine S," known for its effects on fat decomposition and sleep quality improvement, laid the foundation for growth in 2020. The company is also expanding its well-being injection field based on the immune booster "Thymosin," launched in the second half of 2018, and the functional medicine injection "Same injection," approved for depression. Despite challenges from African swine fever and livestock market downturn, the animal pharmaceuticals division grew by over 10%, overcoming a 4% decline in the domestic market. High growth was achieved through the development of differentiated and functional new products, including large-scale swine growth promoters, an improved glutathione injection for stress relief in industrial animals, and differentiated mineral blocks stimulating digestion for Korean cattle. The company plans to launch new products in the companion animal pharmaceuticals market continuously from the first half of 2020 and is working on differentiated formulation research and licensing in of European finished products. In overseas business, Daehan New Pharm expects sales growth in 2020 through active promotion and marketing of its well-being and beauty-related products, showcased at the Manila and Indonesia Philbeauty fairs. Following successful exhibitions in Southeast Asia, the company plans to set up exhibitions and exclusive booths in the emerging Latin American market in the following year to actively promote its product excellence.

In the first half of 2019, Daehan New Pharm achieved sales of 66.8 billion won, marking an 8.6% increase compared to the same period the previous year. Operating profit rose 14.5% to 10.8 billion won, and net profit turned positive, reaching 6.6 billion won. Overall performance improved due to company-wide enhancements in sales efficiency and increased revenue from new product launches, while steady sales continued for existing key products. Steady profits were also generated in the core sectors of obesity and well-being pharmaceuticals, with strong sales expected in the second half of the year. The company plans to maximize performance through visionary management strategies and strengthening its new product portfolio. Financial structure improvements initiated last year and favorable reception of new products contributed to the improved results. The company aims to maintain operational efficiency and continue launching new products to sustain positive momentum throughout the second half.

Daehan New Pharm registered a patent for a method to specifically isolate heterogenetic fibroblasts with excellent skin regeneration effects by separating and culturing only those fibroblasts. Traditional therapies use fibroblasts primarily isolated from dermal tissue behind the ear for treating skin depressions, wrinkles, and refractory dermatitis. However, these treatments are based on mixed fibroblasts, resulting in lower efficacy compared to targeted therapies and cosmetic fillers. The patented method successfully isolates papillary dermal fibroblasts, located in specific dermal areas, known for high proliferative capacity and a central role in skin aging. Applying these in cell therapies is expected to show superior effects compared to conventional fibroblast treatments. The “High-purity isolation method for papillary dermal fibroblasts” uses transwell technology to separate highly active papillary dermal fibroblasts from mixed fibroblast populations. Cells isolated with this method showed about seven times higher levels of papillary dermal fibroblast factors and superior proliferative ability. This increase correlates with repeated culturing and maintaining processes. This purification technology for specific fibroblasts marks Daehan New Pharm's full-scale entry into the cell therapy market. According to Frost & Sullivan, the global cell therapy market is projected to grow at a CAGR of 9.4%, reaching $344 billion by 2021, while the domestic market is growing annually by 25%. Recently, the Bio Research Center relocated to Osong KBIO and is actively advancing biopharmaceutical development. They have developed a high-efficiency cell culture system for fibroblast therapies and are applying serum-free media from their Japanese partner CSTI in cell therapy development.

Daehan New Pharm launched ‘DH Luthione Injection,’ a glutathione (GSH, glutathione sulfhydryl) drug recognized for its powerful antioxidant function, detoxification, and immune-enhancing effects. Glutathione is a small protein composed of three amino acids—cysteine, glutamic acid, and glycine—produced mainly in animal cells, especially in the liver. Its primary functions include antioxidation, detoxification, immune system enhancement, and anti-inflammatory effects. Other antioxidants such as vitamins C and E depend on glutathione, making it the most potent antioxidant known. In industrial animals, glutathione’s functions can prevent productivity loss caused by various stresses and frequent drug exposure, supporting its long-term use in livestock. However, most glutathione products approved for animals are oral formulations, which show low bioavailability due to poor absorption, limiting their effectiveness. Particularly during vaccinations such as foot-and-mouth disease, there was a need to develop injectable formulations that maximize stress relief, reduce inflammation, and boost immunity. To maximize effects, Daehan New Pharm used the same formulation and high-quality raw materials (from Kyowa Hakko Bio Co., Ltd.) as its leading human glutathione injection ‘Luthione Injection’ to develop ‘DH Luthione,’ the first freeze-dried glutathione injectable for animals. Clinical trials at Gyeongsang National University Veterinary College demonstrated that ‘DH Luthione’ effectively reduced stress and inflammation markers (cortisol, TNF-α, CRP) after foot-and-mouth disease vaccination. It significantly increased cell-mediated immunity (IFN-γ) and humoral immunity markers (IgG, IgM, IgA), and improved liver function markers (AST, ALT, bilirubin) while raising albumin levels. These verified benefits make ‘DH Luthione’ a valuable agent for enhancing productivity in industrial animals.

Daehan New Pharm launched ‘TASS-UP,’ a compressed cog thread product for the facial thread lifting market. In August 2018, the company signed an exclusive sales agreement with Gishell Group (CEO Kim Jong-woo) for the premium facial thread lift product ‘TESSLIFTSOFT.’ Following this, by releasing TASS-UP, which is the most popularly used compressed cog thread in the market, Daehan New Pharm has further strengthened its position in the facial thread lifting sector. Facial thread lifting, one of the most popular procedures for maintaining a youthful face, has recently gained popularity over methods like Botox, which have short durations, or fillers that may carry higher risks of side effects. TESSLIFT, launched last year, is known for its 3D mesh structure that provides natural lifting and volumizing effects, with a longer-lasting impact that has made it especially popular among young women. However, patients with sagging skin or deep nasolabial folds require stronger lifting effects. Industry experts emphasize that a combination treatment of compressed cog threads like TASS-UP is necessary for such cases. TASS-UP features thicker cogs than traditional sliced-cut threads, resulting in longer-lasting and more powerful lifting effects, making it suitable for a variety of patients. It is produced using a non-heating process, minimizing degradation of thread components due to heat, which addresses the common problem of thread breakage during long-term storage. Unlike bidirectional cogs, TASS-UP’s three-dimensional cogs are twisted at a consistent angle, enhancing lifting effectiveness. According to ISAPS (International Society of Aesthetic and Plastic Surgery), Korea’s face lifting market is expected to surge from approximately 10 billion won in 2016 to about 35 billion won by 2020. Thread lifting procedures are favored by clinicians due to their relative ease of performance and low incidence of side effects. Dr. Choi Ho-seong of Pionacl Clinic stated, “By using the newly released TASS-UP to achieve strong lifting effects and appropriately combining it with the natural, firm, and long-lasting TESSLIFTSOFT, patient satisfaction can be greatly increased.” Dr. Lee Sang-bong of Wonjin Dermatology Clinic noted, “TASS-UP and TESSLIFTSOFT not only produce synergistic effects but also complement the shortcomings of each thread, enhancing both efficacy and cost-effectiveness.” Daehan New Pharm is strengthening its position as a pharmaceutical bio company specializing in obesity and beauty products. Following a stable launch of facial thread lifting, the company plans to expand its portfolio of facial aesthetic products by introducing various medical devices.

Daehan New Pharm announced on the 14th that its cumulative operating profit for the third quarter increased approximately 44.5% year-on-year to 14.8 billion won. Sales declined about 9% to 90.2 billion won, while net profit turned positive. The significant improvement was driven by expanded sales of high-margin products and the establishment of an efficient management system. The company has been strengthening its product portfolio, improving distribution channels, and optimizing costs, creating a virtuous cycle by reinvesting profits into research and development to drive future growth. Operating efficiency enhancements contributed to performance improvements, with strategic new products such as ‘Same injection’ ‘Thymosin injection,’ and ‘TESSLIFTSOFT’ at the core of ongoing growth efforts. ‘Same injection,’ approved as a treatment for depression, is also known for its excellent effects in cancer adjunct therapy, liver function improvement, and pain management, and is expected to continue the reputation of ‘Luthione Injection’ (commonly known as ‘Baekok Injection’) as a sales leader. The company has an exclusive sales agreement for the premium mesh-structured dissolvable thread ‘TESSLIFTSOFT’ and is actively marketing its differentiated product strengths. Through diversification of sales and improvement of profitability structure, sales increased from 56.7 billion won in 2013 to 130.8 billion won last year, while operating profit rose from 6 billion won to 13.1 billion won.

In the first half of 2018, Daehan New Pharm recorded sales of 61.469 billion won, a decrease of approximately 5% compared to the same period last year. However, operating profit rose significantly by about 44% to 9.46 billion won from 6.563 billion won in the previous year. Due to increased other expenses, the company recorded a net loss of 3.881 billion won. Gradual improvements in financial structure and cost efficiency have steadily strengthened the company's fundamentals. The newly launched non-reimbursed injection ‘Same injection’ and the upcoming anticancer adjunct ‘Thymosin injection’ are expected to contribute to sales growth in the second half, supported by active seminars and both online and offline promotions.